Climate warming has made the planting area of Hami melon expand northward to Barry Bakai Town, Altay City, near 47° N. Climate events often induce the occurrence of pests and diseases in crops, affecting the steady production of Hami melon. In 2013, pests and diseases occurred seriously, resulting in low yield and poor quality of Hami melon. Based on the production survey data of Hami melon in recent 20 years, the interaction of various meteorological factors in different time and different intervals of various factors was analyzed in this paper to explore the characteristics of the meteorological factors that cause diseases and influence the quality of Hami melon.