This research examines whether sweet sorghum, a crop considered more drought-tolerant and suitable for semi-arid areas than corn, could result in an economically viable sweet sorghum ethanol pathway in the Great Plains. We find that that if the D5–D6 RIN price spread exceeds the $0.35/gal recently experienced, the benefits of the pathway would be equivalent to about $90/acre of sweet sorghum, or $0.38/gal of ethanol. Because of sparse cultivation potential, only four the six existing plants in the Nebraska–Colorado High Plains area might expect transportation costs to be low enough for economic feasibility.