Small and medium enterprises play a significant role in economic and industrial development in the developed and developing countries. The main purpose of the study was to investigate the key factors in the effective of growth enterprises. The statistical population of this study according to assessment of Agri-Bank of the Semnan Province includes the managers of enterprises in agricultural sector of Semnan Province who were evaluated as successful enterprises (1932 agricultural units). For determining the sample 125 persons were selected by using Cochran’s formula through stratified random sampling. The main tool for collecting data was questionnaire. The results indicated that 6.4% of agricultural growth enterprises were fully successful, 79.2% were successful, and 13.6% were rather successful. According to the results, there was a significant difference between the achievement levels of growth enterprises in different educational groups with confidence level of 95%. In addition, regression analysis showed that seven variables of initial capital, current production value, years of activity, number of personnel, firm size, investment amount, and business history altogether explained 47.7% of variance in the growth enterprises.