Based on the relevant statistics on the agricultural non-point source pollution in Binzhou City, we studied the spatio-temporal variation in agricultural non-point source nitrogen pollution and phosphorus pollution in Binzhou City during 2008—2015. The results showed that the agricultural non-point source nitrogen pollution and phosphorus pollution in Binzhou City changed from 114400 t and 28800 t in 2008 to 110600 t and 24400 t in 2015, respectively; for the non-point source nitrogen pollution sources, the proportion of chemical fertilizer, manure and domestic sewage changed from 80.41%, 10.47% and 9.13% in 2008 to 82.94%, 4.77% and 12.29% in 2015, respectively; for the non-point source phosphorus pollution sources, the proportion of chemical fertilizer, manure and domestic sewage changed from 89.29%, 8.32% and 2.39% in 2008 to 91.6%, 4.78% and 3.62% in 2015, respectively; in 2015, the non-point source nitrogen pollution was most serious in Wudi County and Huimin County and least serious in Zhanhua County; the non-point source phosphorus pollution was most serious in Zouping County and least serious in Wudi County.