Ninety-six cultivars of tomato were evaluated for natural vims infestation of the tomato yellow leaf cut virus (TYLCV) in two regions of the Dominican Republic. These same cultivars were inoculated with TYLCV early in die growing season and field tests were conducted using plants produced under a shade-bouse. The cultural practices used in the field were similar to those used by the farmers. Data was collected on final yield, infestation rates, percentage of soluble sugars, and presence of the virus using hybridization of nucleic acids. The results suggest that using plants that were protected from the virus infestation can leads to yields of 43.3 t/ha. The majority of the cultivars used for commercial production (canning) aie susceptible lo this disease. However, some cultivars that are used mainly for salads showed a high level of resistance. The best materials were DRS-RH1, DRS-RH2, TY 8479, Gem Star, and PT 1095. The uses of early varieties with good production potential Mem to be an important factor in obtaining an acceptable yield.