The bacterial wilt of potato was first noticed as a new potential tlireat of economic importance in the highland valley of Tirco in 1993. The disease has been disseminated, apparently by infected tuber-seed and plowing implements, and it is currently reported as an important problem in all lowland and highland potato production areas ofthe Dominican Republic. Chemical control attempts have been unsuccessful. The best results have obtained with an integrated approach of cultural practices, emphasizing the use of certified Pseudomonas-free tuber-seeds, crop rotation without susceptible plant species and avoiding excessive irrigation.