In recent years, a spate of dangerous invasive alien species (IAS) have become established in the Caribbean, and many others threaten the region. Some established species continue to spread, causing economic and environmental damage. This paper reviews the status and significance of IAS in the Caribbean. Factors contributing to the upsurge of new problems and pathways are discussed from a perspective of prevention. Steps recently taken to prevent or mitigate the impact of these species are also discussed. On the basis of these experiences, suggestions are made for the future direction of efforts to prevent or manage such invasive species within the Caribbean context.