There is a clear and significant problem with the invasion of basin ecosystems by a wide array of biological agents impacting the social and economic systems, food supply, and unique environments. Basin members share both an interest in and dependency on trade with a great vulnerability to the inherent risks associated with it. Moreover, what threatens one generally is a threat to all. Mostly unilateral, occasional bilateral and few multilateral initiatives have been taken to cope with invasive alien species and more are in the planning stages. Now the challenge is how to take advantage of these initiatives and weave them into a strategic, coordinated set of actions to enhance prevention, exclusion, detection and management of highthreat agents basin-wide. Through this collective security approach, initiatives in regulation development, institution building, training, research, public affairs, and pest/disease/weed management would serve to strengthen safeguarding systems basin-wide.