This study analyzed relationship between techn ical efficiency and socio-economic variables of cassava farmers in Nigeria. Data were collected from randomly sampled 360 cassava farmers in Nigeria using a structured questionnaire. The data were analyzed using descriptive statistics comprising mean, minimum value, maximum value and standard deviation, as well as inferential statistics, which comprised correlation and regression. The findings of the s tudy indicated that a significant relationship exists between technical efficiency and cassava output (0.542), farm income (0.612), processing cost (- 0.414), gari yield (0.608), gross margin (0.483), farming experience (0.278), education (0.699) and extension contact (0.585) of the sampled cassava farmers in Nigeria. Multiple regression result showed that variation in technical efficiency is explained by variations in annual farm income (2.718E-06), annual processing cost (- 1.542E-05), annual gross margin (9.383E-07) farming experience (3.825E-03), education (0.191) and extension contact (6.562E-02). Hence, policy that would enable cassava farmers in Nigeria increase farm income, gross margin and have access to quality education and extension services will lead to the enhancement of technical efficiency of cassava production. Furthermore, policy that would encourage experienced farmers in cassava production and ensure that cost effective improved cassava processing technology is available to the cassava farmers will enhance technical efficiency in cassava production in Nigeria. Policy that would further raise the current level of technical efficiency in cassava production in Nigeria is strongly recommended for the enhancement of the welfare of the cassava farmers in Nigeria.