The root-knot nematode (RKN) Meloidogyne incognita, is a devastating parasite to sweet pepper and is responsible for yield losses up to 15%. RKN is usually controlled by applying synthetic nematicides which have severe negative effects on human health and the environment. These nematicides have been banned from use and producers now seek alternative eco-friendly nematode management strategies. A greenhouse study was conducted to determine the optimum effective doses of NeMax (sesame extract) and Bio Neem (neem extract), and to compare them with Vydate L to evaluate their efficacy at controlling RNI in sweet pepper. From the results, all nematicides caused a reduction in R. similis population density. NeMax at high rates (80 ml/L) was comparable to Vydate L at reducing RKN by over 80% in the roots (P < 0.05). Bio Neem at recommended rates (15 ml/L) was effective at reducing RKN by 52% in the roots and its efficiency in the soil was comparable to NeMax. Vydate L had the fastest knockdown rate of all nematicides but the continuous nematoxic and nematostatic effects of NeMax and Bio Neem prolonged the reoccurrence rate of RKN. The advantages of using these bio-nematicides and their effects on sweet pepper production are discussed.