The University of Queensland (UQ) has a long history as a provider of tertiary programs in agriculture and agricultural research. The rapid decline in enrolments in its core undergraduate programs over the past five years has placed the future of these programs in doubt. This paper identifies four key issues that UQ and the Faculty of Natural Resources, Agriculture and Veterinary Science (NRAVS) must address if it is to meet its aspirations to be recognized for excellence and leadership in agricultural education and research. The four issues relate to collaborating more closely and effectively with the employers of its graduates, collaborating with other universities and agencies in the delivery of its programs, integrating the four disciplinary streams of its programs and widening the appeal of its programs. While this paper concentrates on the analysis of these issues and their management in the context of the agriculture programs at UQ, the issues are relevant to other universities in Australia as they address the impact of declining enrolments and the adequacy of their agriculture programs to meet the challenges that confront the agribusiness sector in the 21st century