Aloe secundiflora Synonym: Aloe floramaculata, Aloe marsabitensis, Aloe engleri belongs to the family Asphodelaceae. Aloe leaf gel and Aloe exudates are the main components. The gel is derived from parenchytomous cells while exudates are derived from the inner epidermal layers. The gel consists of mainly polysaccharides while the exudates consists of a mixture of phenolic compounds mainly athrones, chromones and phenyl pyrones. Leaf components of Aloe have been credited for antibacterial, antifungal and antiviral and anthelmintic medicinal properties. The effectiveness of Aloe secundiflora extracts on the most prevalent nematode of chicken Ascaridia galli was conducted in vitro. The results of this study indicate that Hexane, Ethylacetate, Acetone, Methanol and chloroform extracts were found active in hindering the development of Ascaridia galli eggs to larval stage three (L3), and this was dependent on the concentration of the crude extract. The lowest concentration of the various extracts (5 mg/ml) had an inhibition percent (IP), 75.52%, 79.60%, 87.21%, 86.13% and 43.6% respectively. The highest concentration of the extracts was (50 mg/ml), at this level the inhibition percent was found higher than in the lowest extracts concentrations i.e., 91.84%, 97.55%, 100%, 99.46% and 91.29% respectively. Aloe secundiflora extracts therefore have inhibitory effects on the Ascaridia galli larval development in vitro. Phytochemical tests on the extracts revealed the presence of various chemical compounds.