The main purpose of this research is to determine the potential impact of weather variables on agricultural productivity for Afghanistan, Iran, Pakistan, Turkey and Syria. A translog production function was used in estimating TFP growth in agriculture over the period 1980-2010. Precipitation, temperature, drought and irrigation were included in the analysis. The results indicate increasing agricultural productivity during the period with innovations contributing approximately 30% to agricultural output growth. Temperature and precipitation play a significant role in agricultural production and most frequent extreme drought episodes and irrigation affect, substantially, agricultural productivity growth in the region.