Spas are whales rich in medicinal water, mud, air or other properties that help in the healing process. By analysing the factors of Serbian spa tourism, it can be determined their integrity and importance for the development of certain types of tourism, as well as the importance of these factors for the strengthening of the region in which the spas are located. Can Serbia rely on its own capabilities and resources? The answer to this question should be sought in the successful management of the country, its regions and the state of natural resources, in the establishment of proper national strategy for sustainable development. Given that Serbia has a considerable sources of renewable energy, among which occupies an important place and hydro energy, and that they are not utilized enough, both at the national and regional levels, the paper will try to give an overview of the factors of spa tourism with emphasis on Gamzigrad spa.