This study explores the climate change adaptation strategies for agro crop production and assesses the financial suitability through indigenous knowledge in flood prone areas of Bangladesh. However, for this purpose two types of experiments have conducted with selected eight agro crop species. Firstly, the seven treatments have been experimented in a Tub (an earthen pot). In this case, Tomato (Lycoperscion esculeatum) is more beneficial among these seven treatments and average benefit-cost ratio of this treatment was 3.54. Thereafter, the seven treatments also have been experimenting in Tukri (a bamboo basket). Likewise, Tomato (Lycoperscion esculeatum) is more beneficial in the second experiment and average benefit-cost ratio in this treatment is 3.52 because the soil and the cow dung mixture have been used as a potting medium. On the contrary, Long coriander (Eryngium foetidum) is more beneficial and average benefit-cost ratio in this treatment is 4.74 after using the soil and water hyacinth mixture as a potting medium. According to indigenous knowledge, these results could be developed from different climate change adaptation strategies in farming system for production of common agro crops as well as their financial suitability by the flood affected people of Bangladesh to harness the effect of climate change.