The needs to develop improved varieties of maize have been in the heart of various researchers and institutions in Nigeria because of its strategic role in tackling food insecurity and poverty. Despite substantial efforts to improve maize varieties, the level of adoption of improved maize varieties (IMV) in Nigeria in still very low. Although previous adoption studies have indicated a number of socioeconomic and institutional/organizational variables as important factors influencing adoption of improved maize (crop) varieties in the country, whether these factors are the main issues of concern, and whether the inclusion of regional/agro-ecological variables in adoption model are also important in explaining what could drive farmers’ adoption behaviour requires investigation. This study therefore examined factors influencing adoption of IMV among farmers in Nigeria using a selected portion of the Nigeria Living Standard Measurement Survey data collected by the National Bureau of Statistics and the World Bank for 2010/2011 cropping season with descriptive statistics and probit model as tools for data analysis. The results suggest, in line with some previous studies, that farm size, education level of farmers and access to extension services would significantly influence adoption of IMV. The results also indicate that farmers across the entire agro-ecological regions of country share some negative sentiments regarding adoption of IMV. Renewed emphasis on interventions that would enable farmers gain more access to farmland, and promote formal education and extension service are advocated. An attempt to incorporate variables that capture farmers’ perception/experience on agro-climatic/ ecologically related concerns in adoption study could aid better understand of what drives farmers’ adoption decisions across the country especially in the light of the emerging climate change issues and its implication on food production.