Vietnam is a major pork producing country in Asia, but the pig farmers’ livelihood is threatened by Porcine Reproductive and Respiratory Syndrome (PRRS). Although vaccination is the most practical method of choice for PRRS control, the vaccination percentage is very low. To help inform PRRS vaccine development and policy, our research employed the choice experiment (CE) method to assess pig farmers’ attitudes toward and willingness to pay (WTP) for a PRRS vaccine. The results showed a high positive WTP value for the PRRS vaccination program in Vietnam. This study provides insight into the possibility of increasing the PRRS vaccination percentage.