This work attempts to offer a detailed and informative picture on the use of pendimethalin as a basic herbicide in three crops (cotton, onion, processing tomato) and to assess the economic impacts on farm and regional level. Thus, the economic effectiveness in the farmers’ level is thoroughly examined and the economic impacts in regional level are estimated assuming that farmers do not have at their disposal this herbicide to apply. In addition the stakeholders’ (farmers, processors, experts) views on the economic effectiveness of pendimethalin were recorded and studied by means of two local surveys.