The aim of this paper is discuss how to the application of the modern biotechnology, especially of genetically modified varieties became an important strategy for the strength of the Brazilian agribusiness and worldwide. In this regard, it is addressed the global agribusiness and Brazilian history progress, with the deployment of biotechnology-derived plant varieties. Brazil, a biodiversity rich country is also regarded as a food source for the world, has emerged as a biotechnology power in the international scenario. Furthermore, this essay shows how the use of biotechnology has been important for the development more productive and sustainable agriculture, benefiting from small to large farmers, and increasing the Brazilian competitiveness in the international market. Finally, the market outlook for the biotech agribusiness are discussed and analyzed.