This study was conducted to estimate the profitability of different varieties of wheat in two villages of District Charsadda, Khyber Pakhtunkhwa Province of Pakistan. A total of 100 respondents were interviewed to collect the data on cost and revenue in the target area. 27.2 percent of the area was under wheat cultivation. 38 percent of the respondents were literate while about 52 percent of the wheat growers were owners. Owner cum tenants and tenants were 15 and 33 percent respectively. Simple budgeting technique was used for estimation. The overall total cost of wheat production was Rs. 20760.2 per acre, while for Bakar variety and other varieties total cost of production were , Rs. 21856 and Rs. 22309 per acre respectively. The overall net return was Rs. 13447.3 per acre; while from Baker variety and other varieties net return were Rs. 11825 and Rs. 12425 per acre respectively. OLS estimation technique was used to analyze contribution of major factors in the wheat yield. The sings of the explanatory variables were found according to our prior expectation of the economic theory. The estimated results of yield function indicated that seed rate, FYM (Farm Yard Manure), NPK (Nitrogen, Phospouras and Potassium) and labor days have positive and significant effect on wheat yield, while number of tractor hours and educational level of the growers have positive but statistically insignificant effect. Finally, it is suggested that extension personal should transfer latest technology and diseases free seeds of wheat to the farmer’s for optimum yield.