This study examines male-female wage determination and gender discrimination in Uganda. The study used the nationally representative household survey 2002/03 collected by Uganda bureau of statistics. It was found out that male-female wage gap is about 39%. Wages for both males and females are estimated by implementing a Heckman selection model. Heckman selection model was employed to correct for selectivity at the stage of entrance into the labour market. Estimations from the wage equations both for men and women with sample and sector selection highlight the relevance of human capital, demographic factors and regional labour market segmentation in wage determination. The results from the gender wage gap decomposition using Oaxaca (1973) and Neumark decomposition indicate larger wage differential attributed to discrimination and that the largest component of the unexplained wage gap stems from female disadvantage. The study recommends policies that reduce gender inequalities, particularly those policies that have a positive impact on the empowerment of women who suffer from discrimination like access to education, work environment that encourage equal treatment in labour market.