We select gross national happiness (GNH), per capita GDP, the number of tourists received in rural areas, waste gas emission and other indicators that are closely related to harmonious economic development. Using the indicator data, we establish the multiple linear regression model that is in line with the harmonious economic development model in the Niyang River valley, and conduct empirical analysis. According to the analysis results, the following recommendations are put forward: adhering to laying equal stress on protection and development; improving the quality of the population; protecting environment and curbing environmental pollution; speeding up the construction of ecological environment relying on technology; increasing investment in poverty alleviation to eradicate poverty; extensively mobilizing the public to participate in ecological and environmental protection; coordinating the relationship between the ecological environment and economic development.