This article uses TM images in 1999 and 2006 in Dahua County, selects the driving factors having great impact on urban land use change, and conducts data processing using GIS software. It then uses CLUE-S model to simulate land use change pattern in 2006, and uses land use map in 2006 to test the simulation results. The results show that the simulation achieves good effect, indicating that we can use CLUE-S model to simulate the future urban land use change in karst areas, to provide scientific decision-making support for sustainable development of land use.