Numerous studies have confirmed the importance of both economic and non-economic (or amenity) factors on net domestic migration flows across county boundaries in the U.S. over the past several decades. This study focuses on the counties within the states comprising the Four Corners Region (Arizona, Colorado, New Mexico, and Utah) of the U.S. Initially, regres-sion analysis was employed to explain a proportion of the variation in net migration rates within the region from 1995-2000. Cluster analysis was then used to classify counties into groups that exhibit similar characteristics. The results of the study suggest that only a few of the traditional variables were correlated with migration activity in the Four Corners states; however the cluster-based technique identified four separate county groups which demon-strate the importance of both economic and amenity-based variables.