An investigation of energy consumption saving opportunities in Jordanian pharmaceutical industry has been carried out in this paper, current status of energy consumption, possible saving techniques, and recommendations that could be implemented successfully through Energy Saving Program (ESP) is explored. All variables that influence energy consumption are considered accordingly using a suitable methodology. This methodology integrates a simulation programs into the analysis process; thereafter an accurate analysis and a reliable assessment for energy consumption is provided. HAP 4.41software has been used to simulate and to calculate energy consumption and costs. One biggest Jordanian pharmaceutical facility that produces Penicillin and Cephalosporin products is considered as an illustrative example, the facility consists of four main energy consumption centers and includes consuming systems namely; HVAC (Heating, Ventilating and Air Conditioning system), lighting, compressed air, steam boilers, and miscellaneous equipments like computers, refrigerators, fume hoods, etc. Historical energy consumption quantities are estimated, details of energy data are tabulated accordingly input data files for the computer simulation method using HAP 4.41 are created. Energy saving recommendations has been decided and incorporated into the ESP system. The paper concluded with a good quality room of energy saving opportunities that mirrored positively on the national energy bill with a reduction of 13% of the total annual energy consumption.