Exposure to pollutants in the Great Lakes Region can have significant effects on human health. Some forms of pollution affect humans directly, through the air we breathe and water we drink. Other forms of pollution affect humans indirectly, for example through consumption of contaminated fish. In this paper we describe methods to measure health benefits in monetary and nonmonetary terms in the context of reductions in pollutants as part of a program to improve the environment in the Great Lakes. The paper is meant to be an introduction to this topic for a general audience interested in the Great Lakes.