According to the latest amended agricultural economic statistical data from 1996 to 2009 in Henan Statistical Yearbook-2010，by selecting and establishing the optimized grey model of logarithmic new developed coefficient, we conduct the empirical analysis and forecast research on the grain output and the relevant main economic indices in Henan Province from 2010 to 2015. The results show that the grain output of Henan Province in 2010 will reach 54.8969 million tons, and it will break through 60 million tons at 60.17 million tons in 2015. In years ahead, the grain output of Henan Province will develops to a new stage steadily, which guarantees the national grain supply and socio-economic sustainable development forcibly.