The research aimed at assessment of the influence of weed control methods on the potato yields and economic effects of potato cultivation. A field experiment was carried out in the years 2008-2010. In experiment grown medium-early of table potato cultivar Cekin, which is know in central-eastern Poland. Mechanical and chemical treatment with the used herbicides and their mixtures, increased yield by 50.2% as compared to the control object. The gross margin ranged from 1055,3 PLN for the control object to 11137,0 PLN for object in which weeds controlled with mixture herbicides Command 480 EC + Afalon Dyspersyjny 450 SC.