We examine the economic tradeoff between the costs of pre-event preparedness and post-event response to the potential introduction of an infectious animal disease. In a simplified case study setting, we examine the conditions for optimality of an enhanced pre-event detection system considering various characteristics of a potential infectious cattle disease outbreak, costs of postevent response actions. We show that the decision to invest in pre-event preparedness activities depends on such factors as probability of disease introduction, disease spread rate, relative costs, ancillary benefits, and effectiveness of mitigation strategies.