Objective: To evaluate the effect of potassium silicate and humic substances in the mitigation of salt stress in cucumber grown in a greenhouse.Design/Methodology/Approach: A completely randomized design with factorial arrangement was used. The first factor was the cucumber varieties (Var): Induran (I) and SV2516 (SV). The second factor was potassium silicate (Si), with doses of 0, 10, and 20 mL·L1. The third factor was humic substances (SH), with doses of 0, 10, and 20 kg/ha.Results: The best interaction for the NFP and Y variables was SV*SH20. The N and Ca content in the fruit was I*SH10, while the K and P content was SV*Si20. Meanwhile, Mg, Fe, and Cu interactions stood out with SV*Si10, SV*Si20, and I*Si10, respectively. The best interaction in leaf mineral content was I*SH20 (N), SV*SH10 (P and K), and SV*Si20 (Cu).Study Limitations/Implications: There was no significant difference in Ca, Mg, and Fe in leaf.Findings/Conclusions: At least one of the interactions between cultivars and bio stimulant doses favored agronomic traits, quality, and mineral absorption in fruit.