Objective: To evaluate seed, dry matter, and oil content yield in five accessions of castor oil plant (Ricinus communis L.) in the Altiplano Potosino Zacatecano high plateau regionof Mexico, grown with a fertigation system.Design/Methodology/Approach: Castor was established under a fertigation system on agricultural land. Three levels of fertilization were tested. A completely random experimental design was used, with a 54 factorial arrangement (accessionsfertilization levels) and three repetitions, for a total of 60 experimental units.Results: The following accessions showed an outstandingly favorable response to fertilization: ZACS2C1 (Orito Zac) which had the greater seed yield (735 g) and oil content (%) (50.305.23); and SLPS11C1 which had the greater weight per 100 seeds (g) (56.772.35) and dry matter (1600 g). The best fertilization level for the above mentioned accessions was obtained with the low nutrient solution, while other accessions showed a variable and inverse response to the fertilization level.Limitations/Implications of the study: The study did not imply limitations.Results/Conclusions: The castor oil plant accession from El Orito showed a favorable response to fertilization levels and achieved a higher yield (number of seeds and their oil content), even in the absence of fertilization; consequently, it is a promising accession for agro-industrial crops use.