The effect of different techniques on wine-making was determined, as well as their effect on the physical-chemical characteristics, such as antioxidant activity and phenolic compounds of red wine made with a wild grape (Vitis vilifulia L.). Three wines were analyzed from different areas in Guerrero, Mexico, called Vicario, Reyna and a witness made in the laboratory. The control wine presented higher concentration of tannins and abundant content of anthocyanins (4.5383 mg L1), total phenols (270.743 mg L1), tannic acid, and higher antioxidant capacity (62.27 %), compared to the Reyna and Vicario wines; however, the latter showed a higher content of saponins (++) and °Brix with values of 22.7333 for Vicario and 21.4333 in Reyna. The alcohol content was 27.6 ml 100 mL1 for Vicario and 17 ml 100 mL1 in Reyna, and in terms of titrable acidity, the three wines presented similar values obtaining a general mean of 0.683222 meq L1 of tartaric acid and general mean of IC50 of 0.016577 l. The main differences were attributed to the addition of standard and brown sugar.