@article{Adeoye:334104,
      recid = {334104},
      author = {Adeoye, Bolade K and Oduko, AO and Adeoye, AO and Ayodele,  K and Uwannah NC and Ani,  IF and Oyerinde, OO and  Oyinloye, C},
      title = {Feeding behaviour, weight gain and blood sugar of male  wistar rats fed on a high-calorie diet and vegetables},
      journal = {African Journal of Food, Agriculture, Nutrition and  Development},
      address = {2022},
      year = {2022},
      abstract = {The transition in eating behaviour toward a diet rich in  calories and low in vegetables is a major factor  responsible for the rapid increase in the incidence of  obesity and diabetes. The research aimed at investigating  the effect of a high-calorie diet and vegetables on feeding  behaviour, weight gain and blood sugar in male Wistar rats.  The vegetables were dried, blended, and preserved in  airtight containers. Thirty male Wistar rats weighing an  average of 127.4 g were housed in 6 cages with 5 rats in  each cage. There were six groups comprising the positive  control which was fed standard rat feed and water, also the  negative control which was given a high-calorie diet  (high-fat feed and sugar water) and four treatment groups.  The four treatment groups were fed on a high-calorie diet  with a 5 % concentration of either Corchorus olitorius,  Crassocephalum crepidiodes, Amaranthus hybridus or  Solanecio biafrae respectively. Water (or sugar water) and  feed intake of each group were measured and recorded daily.  Weekly consumption of water and feed was computed for the  entire 5 weeks of the experiment. The fasting blood sugar  and weight of the test rats were recorded at baseline and  weekly. Oral glucose tolerance test and serum insulin were  determined at the end of the experiment using blood samples  from the test rats. All results were analysed using ANOVA  at p≤0.05 and means were separated with the use of Duncan’s  multiple range tests (SPSS 20.0). The high-fat feed was  significantly different from the standard rat feed in the  composition of fat (26.79 g) and calories (422.67 kcal).  The negative control and the treatment groups got adapted  to feeding on the high-calorie diet before the end of the  experimental period. Water and feed intakes of the positive  control were only significantly higher during the first  three and four weeks, respectively. At the end of the  experiment, the positive control had the highest weight  gain of 22 g which was significantly different at p≤0.05.  C. crepidioides and S. biafrae significantly lowered the  blood sugar (62.75 and 62.50 mg/dL) of the test rats. A.  hybridus prevented insulin resistance by the attainment of  peak level at 30 min alongside the positive control. There  was a significant increase in the insulin level of the  negative control while the vegetables prevented increased  production of insulin.},
      url = {http://ageconsearch.umn.edu/record/334104},
      doi = {https://doi.org/10.18697/ajfand.113.21470},
}