This paper analyzed the key issues and challenges confronted in the governance of Village B in the non-epicenter area in rural areas of China during the COVID-19 pandemic. It clarified the weak points in the prevention and control of infectious diseases in Village B. A triple emergency management mechanism of "people-materials-environment" in rural areas should be established. It came up with constructive recommendations for scientifically and effectively responding to public health emergencies in rural non-epicenter areas, which is helpful to improve the rationality, legality and scientific effectiveness of the construction of emergency response mechanisms in rural areas.