This article examines the status of the main biopharming products and estimates the potential acreage involved with biopharming. Our review suggests that important biopharming products of high quality are about to enter the market and they have the potential to provide significant benefits to producers and consumers. Acreage estimates indicate that biopharming may not be a significant source of income for farmers. However, potential acreage requirements warrant the establishment of the right regulatory framework to reduce risks of contamination.