Publication-based indicators of agricultural research activity were developed to assist in the evaluation of the knowledge transfer component of an agricultural research network involving the six Southern Cone countries of South America (Argentina, Bolivia, Brazil, Chile, Paraguay, and Uruguay). The generation of agricultural knowledge in these countries, as reflected by the CAB Abstracts database, has grown by about 50% over the period 1973 to 1982. The academic sector accounts for a substantial amount of this activity, about 40%. There is however significant cross-country variation in these figures. The transfer of agricultural scientific knowledge among agricultural researchers in the region and between these researchers and the world's research community was studied using the SCISEARCH database. The region generally relies heavily on international sources of knowledge; domestic sources are also important, especially in the larger systems; while regional sources are only of minor importance. There is some evidence, however, that in recent years regional sources may have become relatively more important for the smaller research systems. There is also a suggestion that the region's researchers, particularly those in the smaller systems, are drawing on an ageing scientific knowledge base.