Population growth, urbanization and climate change will create future challenges for agribusiness. One particularly vexing challenge will be producing more food using less land and water. Aquaponics offers the potential to overcome these obstacles, but a lack ofresearch providing insight into managerial decision-making in this industry limits its effectiveness. This research is particularly lacking in the realm of aquaponic technological selection. This study compares the expected profitability of four leading aquaponics production systems. It compares expected net present value for coupled and decoupled aquaponic platforms, with and without a co-product capture for organic fertilizer. Technological choice has a considerable impact on aquaponic profitability.Expected net present value estimates ranged from $87,507 to $156,599 across the four technological combinations considered. Decoupled platforms combined with an organic fertilizer co-product capture provided the highest expected net present value. This result holds under a variety of economic conditions.