Animal disease preparedness involves an array of activities to enhance the ability to prevent or mitigate the effects of high consequence diseases. Outbreaks of highly pathogenic avian influenza and virulent Newcastle disease in the last decade tested animal disease preparedness investments in the West and highlighted areas where planning and research are still needed. This paper reflects on those eradication efforts and lessons learned from 2009-2019, as well as future challenges and opportunities pertaining to animal health in Western states, specifically resource limitations, public perceptions, and business continuity plans.