Cluster organizations today are one of the accelerators of economic development. Successful clusters attract professionals, technology and investment, serve a global market and connect with other regional clusters that provide similar activities in the global value chain. The aim of this paper is the study of good practice in the development of clusters by observing the processes that lead to the accelerated development of cluster practices. Cluster organizations in Europe and Serbia are developing at different speeds and with different results. These differences are due to discrepancies in the degree of institutionalization of cluster organizations, financial assistance and the existence of supporting social infrastructure. Results of the paper are intended for policy makers and cluster management in Serbia and the region.