@article{Huisden:256473,
      recid = {256473},
      author = {Huisden, Christiaan M. and Adesogan, Adegbola T. and  Butterweck, Veronika and Szabo, Nancy J. and Gaskin, Jack  M. and Raji, Ademola and Yongning, Lv and Maxwell,  Elizabeth},
      title = {Physiological and Performance Effects on Rats Fed  Detoxified Mucuna pruriens},
      address = {2008-07-13},
      number = {1875-2017-359},
      pages = {10},
      year = {2008},
      abstract = {L-Dopa (3, 4 dihydroxy-L-phenylalanine), a toxic compound  in Mucuna pruriens, causes reduced feed intake, anorexia,  diarrhea, vomiting, skin lesions and potential mortality  when consumed by humans and monogastric livestock.  Processing the bean can reduce L-Dopa in Mucuna beans to  safe levels (< 0.4%), but few studies have examined the  effects of feeding detoxified Mucuna to monogastrics. The  objective of this study was to examine the effect of  feeding detoxified Mucuna bean on the performance,  behavior, and health of rats. Sixty Sprague-Dawley rats  were randomly assigned to five treatments (n=12). Dietary  treatments consisted of a commercial rat chow (CON) or  diets in which 10% of a customized rat chow was replaced  with either undetoxified Mucuna (MUC), or Mucuna detoxified  by acetic acid extraction (pH 3), sodium hydroxide  extraction (pH 11), or ensiling for 28 days (SIL). During  the 14-day trial, behavior, physiological development, and  signs of clinical pathology were evaluated. Necropsy  revealed that MUC caused splenomegaly and monocytosis, and  reduced phosphorus concentrations relative to CON. These  effects were not observed in rats fed detoxified diets,  which alkaline phosphatase concentrations 11-17% greater  than those of MUC, but similar to those of CON. No  abnormalities in behavior, performance, or physiology were  observed in any of the rats on the detoxified diets.  Compared to those fed CON, rats fed Mucunabased diets had  similar feed intake, weight gain, and behavioral results in  the open field. It can be concluded that at the 10% level  of dietary inclusion, there were fewer measurable adverse  effects due to feeding the detoxified Mucuna bean compared  to untreated Mucuna bean.},
      url = {http://ageconsearch.umn.edu/record/256473},
      doi = {https://doi.org/10.22004/ag.econ.256473},
}