The article tried to map the inherent differences stemming from the growth in production area for Brazilian agriculture during the period 1994-2013 within the context of Brazilian mesoregions as well soybeans share in this process. The study employed data from the Brazilian Institute of Geography and Statistics. Cluster Analysis and two increasing indicators were used to identify similarities among the Brazilian agricultural mesoregions, and Locational Quotients and Gini Locational Coefficients were calculated to measure the soybean participative amount in such phenomenon. Results highlight a frontier agricultural area in the central-northwest of Brazil. Concerning the soybean results expose its prominent share in the detected growth of used area for agricultural ends.