Agricultural biotechnology is advancing rapidly and is embracing all major crops. The adoption of genetically modified corn, soybeans, and cotton have reached high levels in the United States. Wheat is the next major crop confronting the biotechnology issue, but no commercial varieties of genetically modified (GM) wheat have been released yet. Primary opportunities for GM developments in wheat center around improvements that meet consumer and end-user needs/issues in addition to meeting producer efficiencies. Developers and proponents of GM wheat must focus on education of consumers and restoration of worldwide confidence in the regulatory systems. The most desired wheat quality trait among millers and bakers is the assurance of consistent quality.