Huanglongbing (HLB) or citrus greening disease has jeopardized the Florida’s signature citrus industry that makes a valuable contribution towards state’s economy. Despite the rigorous efforts to control the disease impact, efficient management measures do not exist. There is limited information on the extent of the impact of the disease. This study provides the measure of the impact of the disease in terms of production loss. Using the regional level data on citrus yield and the tree population we quantified the loss and estimated the probability of loss due to the HLB. The findings demonstrate a substantial production loss in major counties in the Florida. The result further reveals a high probability of loss due to the disease. Higher likelihood of the production loss indicates the ineffectiveness on controlling the impact of the disease.