Based on the background of national food security, this paper analyzes the current situation of food production in Hubei Province that except food yields, overall production situation is not good. Through the food production, storage and circulation, this paper describes the role of food science and technology innovation in food security, and further points out the problems of food science and technology innovation system in Hubei Province, such as disconnection between food science and technology innovation research and food production as well as economic development, backward management system failing to adapt to the needs of agricultural transformation, and low conversion rate of food scientific and technological innovation. Based on this, this paper sets forth the recommendations for food security in Hubei Province.