In order to study the trend of climate change in the future in Weifang, and analyze the impact of climate change on the local wheat production, the air temperature and precipitation in Weifang from 2021 to 2050 were simulated by using the regional climate model PRECIS. And then put the meteorological data into the crop model to simulate the growth of wheat under climate change conditions in the future. The results showed that there would be a trend of rising temperature and increasing precipitation in Weifang in the future. Climate warming would result in growth period of wheat to be ahead of schedule and yield reduction. If taking into account the effect of CO2, the yield of wheat would increase.