Crop rotation systems are a commonly used production practice with primary benefits including the suppression of soil pathogens and crop pests as well as the reduction of soil nutrient depletion. Realized economic benefits are observed as increased revenue resulting from higher yields, or as reduced pesticide or fertilization expenses. In some instances, the inclusion of one crop in a rotation system may impose costs on another crop. A rice/crawfish rotation is utilized as a case study in this article to illustrate this relationship and to present implications for enterprise cost assignment and land tenure adjustments in situations where this relationship might occur.