@article{Laxminarayan:10619,
      recid = {10619},
      author = {Laxminarayan, Ramanan and Brown, Gardner M., Jr.},
      title = {Economics of Antibiotic Resistance: A Theory of Optimal  Use},
      address = {2000},
      number = {1318-2016-103445},
      series = {Discussion Paper 00-36},
      pages = {37},
      year = {2000},
      abstract = {In recent years bacteria have become increasingly  resistant to antibiotics, leading to a decline in the  effectiveness of antibiotics in treating infectious  disease. This paper uses a framework based on an  epidemiological model of infection in which antibiotic  effectiveness is treated as a nonrenewable resource. In the  model presented, bacterial resistance (the converse of  effectiveness) develops as a result of selective pressure  on nonresistant strains due to antibiotic use. When two  antibiotics are available, the optimal proportion and  timing of their use depends precisely on the difference  between the rates at which bacterial resistance to each  antibiotic evolves and on the differences in their  pharmaceutical costs. Standard numerical techniques are  used to illustrate cases for which the analytical problem  is intractable.},
      url = {http://ageconsearch.umn.edu/record/10619},
      doi = {https://doi.org/10.22004/ag.econ.10619},
}