This study investigates how the implementation and standards harmonization of HACCP regulation affects U.S. seafood exporting based on the method of Gravity Model and Spatial Error model. The analysis includes top 32 countries that importing seafood from U.S. The results indicate that HACCP standards benefit U.S. seafood exporting in the long time period but do not have significant impact in the short term period. Moreover, the way of performance standards is better for HACCP implementation and standards harmony.