Dominant users of Lake Okeechobee water resources are agricultural producers and recreational anglers. These uses will be directly affected, should the lake become infested with zebra mussels. We employ a probabilistic bioeconomic simulation model to estimate the potential impact of zebra mussels on consumptive water uses, recreational angling, and wetland ecosystem services under alternative public management scenarios. Without public management, the expected net economic impact from zebra mussels is - $244.1 million over 20 years. Public investment in prevention and eradication will yield a net expected gain of +$188.7 million, a superior strategy to either prevention or eradication alone.