We developed Dynamic Inter Regional Computable General Equilibrium (IRCGE) for Energy and Agriculture Model that incorporates geographic features into CGE. Within the context of comparative advantage we demonstrate how the biofuel policy impact on trade and food security. We find that biofuel policy may benefit for exporters countries which mostly are developing countries and cost for importers countries . In term of geographical analysis, European Union may trading with neighbor country and independent for biofuel commodities from developing countries. Meanwhile, food security issues in developing countries may lead more fluctuated price in agriculture price than in developed countries; in supply side trade liberalization may increase in welfare export and output accordingly.